pulmonary inflammation – Communicable Diseases Research

Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway

Article

Published on 2023-01-302022-11-16
Journal: Journal of ethnopharmacology
[Category] 신종인플루엔자, 치료기술,

B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman Primates

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulence. virulent VoC VOCs were infected
[DOI] 10.1128/spectrum.02263-22 PMC 바로가기

Novel application of [18F]DPA714 for visualizing the pulmonary inflammation process of SARS-CoV-2-infection in rhesus monkeys (Macaca mulatta)

Article

Published on 2022-09-012022-11-16
Journal: Nuclear medicine and biology
[Category] COVID19(2023년), SARS, 치료기술,

The efficacy of combined therapy of qingfeiPaidu capsule and lianhuaqingwen capsule nursing interventions for hospitalized patients with COVID-19: A retrospective study of medical records

Randomized Controlled Trial

Published on 2022-08-122022-10-04
Journal: Medicine
[Category] 임상,

[키워드] affecting alleviate anti-inflammatory effect baseline Blood Blood urea nitrogen C-reactive protein caused Chinese circulating Clinical characteristics clinical symptom Clinical symptoms Combined Combined therapy COVID-19 COVID-19 patient criteria demonstrated discharge Efficacy enrolled global pandemic group groups Hospitalization hospitalized patient immune function individuals Inflammation Intervention Laboratory lactate dehydrogenase life-threatening lung Lymphocyte count medical record Medicine Mild Moderate COVID-19 outcome outcomes Patient patients with COVID-19 Prognosis pulmonary inflammation Randomly Retrospective study severity scores therapy Traditional Treatment were recorded White blood cells
[DOI] 10.1097/MD.0000000000029964 PMC 바로가기 [Article Type] Randomized Controlled Trial

TRPC6 is altered in COVID-19 pneumonia

TRPC6은 COVID-19 폐렴에서 변경됩니다.

Article

Published on 2022-08-012022-09-11
Journal: Chemico-biological interactions
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] aggravate alveolar septa anatomical Capillaries cellular ciliated ciliated epithelium cough COVID COVID pneumonia COVID-19 COVID-19 pneumonia Dissection dissections distribution drugs Fever fibrosis Gene Expression Human human lung human lung tissue hyaline membrane hyaline membranes immunohistochemistry Inflammation inflammatory lesions inhibiting investigated involved lesions lung lung; molecular mechanism molecular mechanisms observation observations patients with COVID-19 Pneumonia pneumoniae processed Protein pulmonary inflammation reported Support Symptom target Therapies Therapy. tissue tissues TRP TRPC6 TRPC6 channels vessel wall was obtained
[DOI] 10.1016/j.cbi.2022.109982 PMC 바로가기 [Article Type] Article

SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl – accumulation in respiratory epithelium

SARS-CoV-2 뉴클레오캡시드 단백질은 단백질-단백질 상호작용 매개 세포내 Cl-호흡 상피에서의 축적을 통해 과염증을 유발합니다

Article

Published on 2022-07-272022-09-11
Journal: Signal Transduction and Targeted Therapy
[Category] COVID19(2023년), SARS, 신약개발, 치료법,

[키워드] abrogated Airway inflammation CAMP cell lines cells CFTR Concentration COVID-19 cystic fibrosis Cytokine storms Defense demonstrated depleting downregulated elicit epithelial epithelial cell epithelial cells expression fibrosis glucocorticoid Host host defense human airway epithelial hyperinflammation immune response immune responses Inflammatory response Inflammatory responses inhibition inhibitor Intracellular knockout microRNA modulating murine model murine models N protein pathogen phosphodiesterase Phosphorylation promoted Protein pulmonary inflammation raised reducing regulated respiratory epithelium resulting robust Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid second messenger selective serum SGK1 signaling pathway Smad3 structural protein suggested sustained targeting therapeutic strategy transmembrane Trigger upregulation
[DOI] 10.1038/s41392-022-01048-1 PMC 바로가기 [Article Type] Article

Whole-genome sequencing reveals host factors underlying critical COVID-19

전체 게놈 시퀀싱은 중요한 COVID-19의 기저에 있는 숙주 요인을 밝힙니다

Article

Published on 2022-07-012022-09-11
Journal: Nature
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, 치료제,

[키워드] Adhesion Molecule Antigen association associations ATP11A BCL11A caused CD209 Coagulation coagulation factor Colocalization Control COVID-19 Critical Critical care Critical disease Critical illness Critically ill disease disease severity Evidence expression Factor failure FUT2 Gene Expression Genetic variation genetics Genome genomes GenOMICC Hospitalization Host ICAM5 identify IL10RB Immune-mediated increased expression independent individual infection with SARS-CoV-2 inflammatory lung injury influence interferon intravascular coagulation involved leucocyte life-threatening Lung injury mechanism mechanisms membrane mendelian randomization MUC1 mucin myeloid cell pathophysiology PLSCR1 provide pulmonary inflammation reduced replicate reveal SELE Sequencing significantly Support targets transcriptome-wide underlying disease variant variants Viral viral replication whole-genome sequencing
[DOI] 10.1038/s41586-022-04576-6 PMC 바로가기 [Article Type] Article

SARS CoV-2 (Delta Variant) Infection Kinetics and Immunopathogenesis in Domestic Cats

SARS CoV-2(Delta Variant) 감염 역학 및 국내 고양이의 면역 병인 발생

Article

Published on 2022-06-012022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2-expressing cell ACE2-expressing cells acute COVID-19 acute infection animal model animal models B.1.617.2 chemokine chemokine signaling circulating Clinical sign Cluster correlated correlation COVID-19 disease COVID-19 disease course Critical cytokine receptor Delta delta variant develop differentially expressed gene Differentially expressed genes disease Disease progression disease transmission Divergence domestic cats dose downstream dysregulated evaluate feline ferrets flexible genetic modification help highlight Host hub genes identify immunopathology include Infection Infectious virus Inflammatory inflammatory pathways inoculated Interaction interactions intranasally Kinetics lesion lesions limitation lung lung tissue Lungs Mild nasal network analysis non-human primates pathology pathology. pathway peribronchial Pneumocytes Post-infection Prevent progression pulmonary inflammation pulmonary lesion pulmonary lesions Respiratory disease RNA sequencing SARS CoV SARS CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants secretion significantly Spread target therapeutic timepoints transgenic mice translational upregulation variant Vascular endothelium Vasculitis Viral antigen Viral protein virus WGCNA wild-type SARS-CoV-2
[DOI] 10.3390/v14061207 PMC 바로가기 [Article Type] Article

How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment

혈액의 타고난 면역 체계가 COVID-19 유발 ARDS의 전신 병리에 기여하고 치료를 위한 잠재적인 표적을 제공하는 방법

Review

Published on 2022-03-082022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Activation Acute kidney injury acute respiratory distress acute respiratory distress syndrome AMY-101 Angiogenesis apoptotic cells ARDS Biomarker bradykinin candidate drug candidate drugs cascade cascade system characterized chemokines Coagulation Coagulation system complement Complement inhibitor complement inhibitors Compound COVID-19 Crosstalk cytokine Cytokines damaged demonstrated dysregulation ecallantide eculizumab Evidence favor ground glass opacities heparin High dose high risk Icatibant IL-6 IL-6 levels in some incidence include Influenza influenza-like symptom Influenza-like symptoms inhibitor initiated Innate innate immune system intensive care treatment Kallikrein lanadelumab lead leukocytes life-threatening LMWH Lung injury mechanical ventilation mechanism moderate MOST oxygen oxygen saturation pandemic pathophysiology Patient patients Phase I plasma plasma proteins Platelets platelets. Potential predict Prevent Prognostic value pulmonary damage pulmonary inflammation receptor reduced Regulation respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 infected patient severity Support survival syndrome System systemic target the disease therapeutic option therapeutic options Thromboembolism thrombosis thrombotic Thrombotic complications translated Treatment treatment of COVID-19 Trial Usage Vascular ventilator virus
[DOI] 10.3389/fimmu.2022.840137 PMC 바로가기 [Article Type] Review

Dihydroartemisinin attenuates pulmonary inflammation and fibrosis in rats by suppressing JAK2/STAT3 signaling

Research Paper

Published on 2022-02-152022-10-28
Journal: Aging (Albany NY)
[Category] COVID-19,

[키워드] activated Activation alveolar inflammation analyzed attenuate cause caused CCL3 change chemokine collagen Coronavirus disease 2019 COVID-19 dihydroartemisinin effective expression fibrosis growth hydroxyproline IL-6 Inflammatory response inhibit inhibited inhibiting inhibitory effect JAK2 JAK2/STAT3 JAK2/STAT3 signaling janus lung Lung injury lung tissue molecular analysis molecular mechanism Necrosis phosphorylated pulmonary fibrosis pulmonary inflammation reduced representing SARS-CoV-2 serum Signaling staining STAT3 TGF-β1 therapeutic therapeutic effect TNFα treat Treatment with COVID-19 worldwide pandemic
[DOI] 10.18632/aging.203874 PMC 바로가기 [Article Type] Research Paper